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| 19.11.2021 | 18:30 | Hannover 96 | - | SC Paderborn 07 | 0:0 (0:0) | |
| 18:30 | SV Sandhausen | - | 1. FC Nürnberg | 1:2 (0:0) | ||
| 20.11.2021 | 13:30 | Hamburger SV | - | Jahn Regensburg | 4:1 (2:1) | |
| 13:30 | SV Darmstadt 98 | - | FC St. Pauli | 4:0 (4:0) | ||
| 13:30 | Hansa Rostock | - | Erzgebirge Aue | 1:2 (1:1) | ||
| 20:30 | Werder Bremen | - | FC Schalke 04 | 1:1 (0:0) | ||
| 21.11.2021 | 13:30 | 1. FC Heidenheim 1846 | - | Holstein Kiel | 2:1 (1:1) | |
| 13:30 | Dynamo Dresden | - | Fortuna Düsseldorf | 1:0 (1:0) | ||
| 13:30 | FC Ingolstadt 04 | - | Karlsruher SC | 1:1 (1:1) |
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
FC St. Pauli | 14 | 9 | 2 | 3 | 31:16 | 15 | 29 |
| 2 |
|
SV Darmstadt 98 | 14 | 8 | 2 | 4 | 35:16 | 19 | 26 |
| 3 |
|
SC Paderborn 07 | 14 | 7 | 4 | 3 | 28:16 | 12 | 25 |
| 4 |
|
Jahn Regensburg | 14 | 7 | 4 | 3 | 30:19 | 11 | 25 |
| 5 |
|
1. FC Nürnberg | 14 | 6 | 6 | 2 | 19:12 | 7 | 24 |
| 6 |
|
Hamburger SV | 14 | 5 | 8 | 1 | 24:16 | 8 | 23 |
| 7 |
|
FC Schalke 04 | 14 | 7 | 2 | 5 | 23:17 | 6 | 23 |
| 8 |
|
1. FC Heidenheim 1846 | 14 | 6 | 3 | 5 | 15:20 | -5 | 21 |
| 9 |
|
Werder Bremen | 14 | 5 | 5 | 4 | 20:20 | 0 | 20 |
| 10 |
|
Karlsruher SC | 14 | 4 | 6 | 4 | 21:21 | 0 | 18 |
| 11 |
|
Hansa Rostock | 14 | 5 | 2 | 7 | 17:24 | -7 | 17 |
| 12 |
|
Fortuna Düsseldorf | 14 | 4 | 4 | 6 | 19:21 | -2 | 16 |
| 13 |
|
Dynamo Dresden | 14 | 5 | 1 | 8 | 15:18 | -3 | 16 |
| 14 |
|
Erzgebirge Aue | 14 | 3 | 5 | 6 | 13:20 | -7 | 14 |
| 15 |
|
Hannover 96 | 14 | 3 | 5 | 6 | 10:18 | -8 | 14 |
| 16 |
|
Holstein Kiel | 14 | 3 | 5 | 6 | 15:25 | -10 | 14 |
| 17 |
|
SV Sandhausen | 14 | 3 | 3 | 8 | 14:28 | -14 | 12 |
| 18 |
|
FC Ingolstadt 04 | 14 | 1 | 3 | 10 | 9:31 | -22 | 6 |
| Promotie | |
| Promotie en degradatie | |
| Promotie en degradatie | |
| Degradatie |
